Different Patterns of Virulence Genes in Streptococcus mutans and Streptococcus sobrinus Originating from Estonian Toddlers—Mothers Cohort

Aims: Mutans streptococci include Streptococcus mutans and sobrinus, which can cause tooth decay. The current study aimed to compare their virulence genes with each other correlate them the clinical data of patients. Materials methods: Altogether 21 S. 19 sobrinus strains were investigated, originating from 24 children (age 2.7 ± 0.4 years) 13 mothers (27.3 3.7). PCR method was applied detect 11 genes. Caries indices (dmf, decayed/missing/filled; DMFT, decayed/missing/filled teeth) SM score (Mutans amount in saliva) recorded. Results: Most harbored all studied, while had significantly fewer gbpA, gbpB, wapA ftf present isolates spaP, gtfB, vicR, SMU.1037c SMU.105 41–88% isolates, gtfD SMU.104 absent studied. A positive correlation appeared between biofilm-related vicR polysaccharide-production-related In contrast, another gtfB gene some cases lacking or gene. Positive association found presence adhesion-related spaP pediatric-derived an increase score. Conclusions: Differences exist two common species streptococci: have more than that both crucial enhancing. Deeper research is needed clarify mechanisms behind increased cariogenicity cohabitation.